CCCP

Item no.	TMO-T7081-25mg
Manufacturer	TargetMol
CASRN	555-60-2
Amount	25 mg
Quantity options	100 mg 1 mL x 10 mM (in DMSO) 1 mL 200 mg 25 mg 500 mg 50 mg
Category	Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
Purity	0,98
Citations	1. Kwon D, et al. Carbonyl cyanide 3-chlorophenylhydrazone (CCCP) suppresses STING-mediated DNA sensing pathway through inducing mitochondrial fission. Biochem Biophys Res Commun. 2017 Aug 30. pii: S0006-291X(17)31704-7.
Smiles	ClC1=CC=CC(N\N=C(/C#N)C#N)=C1
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	Carbonyl Cyanide m-Chlorophenylhydrazone,Carbonyl cyanide 3-chlorophenylhydrazone
Shipping Condition	Cool pack
Available
Manufacturer - Targets	IκB/IKK\|\|\|Apoptosis\|\|\|Mitochondrial Metabolism\|\|\|STING\|\|\|COX\|\|\|IFNAR\|\|\|Antibacterial
Shipping Temperature	Cool pack
Storage Conditions	-20
Molecular Weight	204.62
Description	CCCP (Carbonyl Cyanide m-Chlorophenylhydrazone) is an oxidative phosphorylation (OXPHOS) inhibitor and mitochondrial proton carrier uncoupler. CCCP inhibits the activation of STING and its downstream signaling molecules TBK1 and IRF3.
Pathways	Metabolism\|\|\|Immunology/Inflammation\|\|\|Microbiology/Virology\|\|\|Apoptosis\|\|\|Neuroscience\|\|\|NF-κB
Bioactivity	CCCP inhibits activation of STING and its downstream signalling molecules, TBK1 and IRF3. CCCP inhibits STING-mediated IFN-beta production via disrupting mitochondrial membrane potential (MMP).
Receptor	TBK1; IFN-beta

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

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