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Cynomolgus Thrombopoietin R / TPO R Protein, His Tag (MALS & SPR verified)

Cynomolgus Thrombopoietin R / TPO R Protein, His Tag (MALS & SPR verified)

Item no.	THR-C52H3-100ug
Manufacturer	ACROBiosystems
Amount	100 ug
Format	Solid
Specific against	Monkey (Cynomolgus, Simian)
Host	HEK293
Conjugate/Tag	Unconjugated, HIS
Purity	90%
Shipping condition	Room temperature
Available
Manufacturer - Category	Protein
Manufacturer - Conjugate / Tag	C-10×His, Unconjugated
Shipping Temperature	RT
Storage Conditions	-20°C
Molecular Weight	54.3 kDa
Description	Cynomolgus Thrombopoietin R Protein, His Tag (THR-C52H3) is expressed from human 293 cells (HEK293). It contains AA Gln 22 - Thr 489 (Accession # A0A2K5UGC7).
Background	Thrombopoietin R, also known as TPO-R, is expressed predominantly on the surface of MKs, platelets, hemangioblasts, and hematopoietic stem cells (HSCs). Binding of TPO to the megakaryocyte TPO-R leads to different effects: prevention of megakaryocyte apoptosis; increased megakaryocyte number, size, and ploidy; increasing rate of megakaryocyte maturation; and internalization of the TPO/TPO-R complex. Thrombopoietin R involved in multiple signal transduction pathways, such as JAK, STAT, and MAP kinase.
Molecule	Thrombopoietin R
Exp Region	Gln 22 - Thr 489
Characteristics	This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 54.3 kDa. The protein migrates as 60-65 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin	1.0 EU per μg
Buffer	PBS, pH7.4
Stability	-20°C to -70°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution._x000D_For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100 ug

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Delivery expected until 6/19/2025