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Afatinib

Afatinib

Item no.	TMO-T21312-500mg
Manufacturer	TargetMol
CASRN	850140-72-6
Amount	500 mg
Quantity options	100 mg 1 mL x 10 mM (in DMSO) 10 mg 1 mL 200 mg 25 mg 500 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
Smiles	N(C=1C2=C(C=C(O[C@H]3CCOC3)C(NC(/C=C/CN(C)C)=O)=C2)N=CN1)C4=CC(Cl)=C(F)C=C4
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	Afatinib free base,BIBW 2992
Shipping Condition	Cool pack
Available
Manufacturer - Targets	EGFR\|\|\|Autophagy
Shipping Temperature	Cool pack
Storage Conditions	-20
Molecular Weight	485.94
Description	Afatinib (BIBW 2992) is an irreversible inhibitor of the EGFR family (EGFR-wt, EGFR-L858R, EGFR-L858R/T790M, and HER2) with IC50s of 0.5 nM, 0.4 nM, 10 nM, and 14 nM, respectively.
Pathways	Tyrosine Kinase/Adaptors\|\|\|Angiogenesis\|\|\|Autophagy\|\|\|JAK/STAT signaling

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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