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J-104132

J-104132

Item no.	TMO-T27647-25mg
Manufacturer	TargetMol
CASRN	198279-45-7
Amount	25 mg
Quantity options	100 mg 25 mg 500 mg 50 mg 5 mg
Category	Reagents & Chemicals Biochemicals
Type	Chemicals
Specific against	other
Smiles	C(O)(=O)[C@H]1[C@@H](C=2C([C@@H]1C=3C=C4C(=CC3)OCO4)=CC=C(CCCC)N2)C5=C(C[C@@H](C(O)=O)C)C=C(OC)C=C5
ECLASS 10.1	32160000
ECLASS 11.0	32160000
UNSPSC	12000000
Alias	L753037,L 753037,J104132,J 104132,L-753037
Shipping Condition	Cool pack
Available
Manufacturer - Targets	Others
Shipping Temperature	Cool pack
Storage Conditions	-20
Molecular Weight	531.6
Description	J-104132 is a potetn and selective endothelin A/B receptor antagonist (Ki: cloned human ETA = 0.034 nM; cloned human ETB = 0.104 nM) . In vitro, J-104132 is a potent antagonist of ET-1-induced accumulation of [3H]inositol phosphates in Chinese hamster ovary cells stably expressing cloned human ETA receptors (IC50 = 0.059 nM). Pretreatment with J-104132 prevents the lethal response to ET-1 when administered i.v. (ED50 = 0.045 mg/kg) or p.o. in fed animals (ED50 = 0.35 mg/kg).
Pathways	Others

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 25 mg

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