Comparison

TL12-186 European Partner

Item no. TMO-T34888-50mg
Manufacturer TargetMol
CASRN 2250025-88-6
Amount 50 mg
Quantity options 100 mg 1 mL x 10 mM (in DMSO) 10 mg 1 mg 200 mg 25 mg 2 mg 50 mg 5 mg
Category
Type Chemicals
Specific against other
Smiles O=C1NC(=O)C(N2C(=O)C=3C=CC=C(NCC(=O)NCCOCCOCCN4CCN(C5=CC=C(C=C5)NC6=NC=C(Cl)C(=N6)NC=7C=CC=CC7S(=O)(=O)C(C)C)CC4)C3C2=O)CC1
ECLASS 10.1 32160000
ECLASS 11.0 32160000
UNSPSC 12000000
Alias TL12 186,TL12186
Shipping Condition Cool pack
Available
Manufacturer - Targets
PROTACs|||CDK
Shipping Temperature
Cool pack
Storage Conditions
-20
Molecular Weight
931.46
Description
TL12-186 is a Cereblon-dependent kinase degrader that degrades CDK, BTK, FLT3, Aurora and other kinases.TL12-186 inhibits CDK2/cyclin A and CDK9/cyclin T1 with IC50s of 73 and 55 nM, respectively.
Pathways
PROTAC|||Cell Cycle/Checkpoint

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Amount: 50 mg
Available: In stock
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