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5(S),12(S)-DiHETE

5(S),12(S)-DiHETE

Item no.	TMO-T37649-50ug
Manufacturer	TargetMol
CASRN	79056-01-2
Amount	50 ug
Quantity options	100 ug 1 mg 25 ug 50 ug
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Smiles	CCCCC\C=C/C[C@H](O)\C=C\C=C/C=C/[C@@H](O)CCCC(O)=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Shipping Condition	Cool pack
Available
Manufacturer - Targets	Others
Shipping Temperature	Cool pack
Storage Conditions	-20
Molecular Weight	336.472
Description	5(S), 12(S)-DiHETE is a natural bioactive lipid derived from arachidonic acid . It is synthesized by glycogen-induced rabbit peritoneal polymorphonuclear leukocytes (PMNLs) incubated with AA. 5(S), 12(S)-DiHETE can be produced by successive oxygenation of AA by 5-lipoxygenase (5-LO) in platelets and 12-LO in leukocytes. It can also be synthesized from 12(S)-HETE by 5-LO, in the presence of 5-LO activating protein (FLAP), activated with calcium ionophore. 5(S), 12(S)-DiHETE is an epimer of leukotriene B4 that is weakly chemotactic for PMNL.
Pathways	Others

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