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Topoisomerase II inhibitor 3

Topoisomerase II inhibitor 3

Item no.	TMO-T61283-25mg
Manufacturer	TargetMol
CASRN	99140-25-7
Amount	25 mg
Quantity options	100 mg 100 mg 25 mg 25 mg 50 mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Smiles	N(=O)(=O)C1=C2C(=C(NCCCN(C)C)C=C1)C(=O)C=3C(N2)=CC=C(O)C3
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Shipping Condition	Cool pack
Available
Manufacturer - Targets	Apoptosis\|\|\|Topoisomerase\|\|\|Others
Shipping Temperature	Cool pack
Storage Conditions	-20°C
Molecular Weight	356, 38
Description	Topoisomerase II inhibitor 3 (Compound 6 h) is an acridone derivative acting as a Type II DNA topoisomerase (topo II) inhibitor. It specifically targets topo IIα/β subtypes, with IC50 values of 0.17 μM for topo IIα and 0.23 μM for topo IIβ, causing significant DNA damage and inducing apoptosis by triggering the loss of mitochondrial membrane potential [1].
Pathways	Others\|\|\|DNA Damage/DNA Repair\|\|\|Apoptosis

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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