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FGFR4-IN-14

FGFR4-IN-14

Item no.	TMO-T79271-5mg
Manufacturer	TargetMol
Amount	5 mg
Quantity options	50 mg 50 mg 5 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Shipping Condition	Cool pack
Available
Manufacturer - Targets	FGFR
Shipping Temperature	Cool pack
Storage Conditions	-20°C
Molecular Weight	522, 43
Description	FGFR4-IN-14 (Compound 27i) is a selective FGFR4 inhibitor with an IC50 of 2.4 nM, effectively inhibiting cell proliferation in V550L and N535K mutant strains. It shows IC50 values of 21 nM against Huh7 cells, 2.5 nM against BaF3/ETV6-FGFR4-V550L cells, and 171 nM against BaF3/ETV6-FGFR4-N535K cells. FGFR4-IN-14 demonstrates significant antitumor efficacy in the Huh7 xenograft model and is utilized in hepatocellular carcinoma (HCC) research [1].
Pathways	Angiogenesis\|\|\|Tyrosine Kinase/Adaptors

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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