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WISP1/CCN4 Protein, Mouse, Recombinant (His)

WISP1/CCN4 Protein, Mouse, Recombinant (His)

Item no.	TMO-TMPK-00732-100ug
Manufacturer	TargetMol
Amount	100 ug
Quantity options	100 ug 100 ug 10 ug 1 mg 200 ug 20 ug 500 ug 500 ug 50 ug 5 ug
Category	Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	ELM-1,WISP1tc,WISP1c,CCN4,WISP-1,WISP1i
Shipping Condition	Cool pack
Available
Shipping Temperature	Cool pack
Storage Conditions	-20°C
Molecular Weight	39.4 kDa (predicted). Due to glycosylation, the protein migrates to 64-68 kDa based on Tris-Bis PAGE result.
Description	The interplay between glioma stem cells (GSCs) and the tumor microenvironment plays crucial roles in promoting malignant growth of glioblastoma (GBM), the most lethal brain tumor. WISP1 is preferentially expressed and secreted by GSCs. Silencing WISP1 markedly disrupts GSC maintenance, reduces tumor-supportive TAMs (M2), and potently inhibits GBM growth. WISP1 signals through Integrin α6β1-Akt to maintain GSCs by an autocrine mechanism and M2 TAMs through a paracrine manner.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100 ug

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