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Purified Anti-Mouse CD62L (L-Selectin) (MEL-14)

Purified Anti-Mouse CD62L (L-Selectin) (MEL-14)

Manufacturer	Tonbo Biosciences
Category	Neuroscience Neural Lineage Markers Neural Signaling Neural Adhesion Molecules Antibodies Cell Biology Cell Movement Cell Adhesion Flow Cytometry Immunohistochemistry Immunoprecipitation Primary Antibodies Electron Microscopy
Type	Antibody Monoclonal
Specific against	Mouse
Clone	MEL-14
Isotype	IgG2a kappa
Format	Purified
Applications	FC, IP, IHC, EM, FA
Amount	100 ug
Host	Rat
Item no.	70-0621-U100
Targets	SELL;;SELP
eClass 6.1	32160702
eClass 9.0	42030590
Available
Description	The MEL-14 antibody is specific for mouse CD62L, also known as L-Selectin, a cell adhesion molecule which facilitates lymphocyte " rolling" on activated vascular endothelium and homing to high endothelial venules (HEV) as immune cells transmigrate from blood into peripheral tissues. L-Selectin is a member of a family of Selectin molecules which act together with the integrin family of adhesion molecules to mediate leukocyte-endothelial interactions. L-Selectin is characteristically expressed by neutrophils, and is also found on B cells, monocytes, granulocytes, and at varying levels on naive, effector and memory T cells. It is rapidly shed upon cell activation, releasing into the circulation a soluble form whose biological role is of particular interest in cancer biology research. The MEL-14 antibody may be used as a phenotypic marker for CD62L expression on a variety of immune cell types. Please note that CD62L (L-Selectin) itself is also referred to as MEL-14 in the literature.
Alternative Names	LECAM-1, Ly-22
Gene ID	20343
Citations	Lee L-F, Logronio K, Tu GH, Zhai W, Ni I, Mei L, Dilley J, Yu J, et al. 2012. Proc. Natl. Acad. Sci. 10.1073. (Flow cytometry). Harp JR, Gilchrist MA, and Onami TM. 2010. J. Immunol. 185:5751-5761. (in vivo blocking) Furukawa Y, Umemoto E, Jang MH, Tohya K, Miyasaka M, and Hirata T. 2008. J. Biol. Chem. 283: 12112-12119. (Immunoelectron microscopy) Li Y, Brazzell J, Herrera A, and Walcheck B. 2006. 108: 2275-2279. (Immunoprecipitation) Ochando JC, Yopp AC, Yng Y, Garin A, Li Y, Boros P, Llodra J, Ding Y, Lira SA, Krieger NR, and Bromberg JS. 2005. J. Immunol. 174: 6993-7005. (in vivo blocking, Flow cytometry) Zhao L-C, Shey M, Farnsworth M, and Dailey MO. 2001. J. Biol. Chem. 276: 30631-30640. (Immunoprecipitation) Suzuki A, Andrew DP, Gonzalo JA, Fukumoto M, Spellberg J, Hashiyama M, Takimoto H, Gerwin N, Webb I, Molineux G, Amakawa R, Tada Y, Wakeham A, Brown J, McNiece I, Ley K, Butcher EC, Suda T, Gutierrez-Ramos JC, and Mak TK. 1996. Blood. 87:3550-3562. (Stamper-Woodruff assay; in vivo blocking) Reichert RA, Jerabek L, Gallatin WM, Butcher EC, and Weissman IL. 1986. 136(10): 3535-3542. (Immunohistochemistry)

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

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Amount: 100 ug

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Delivery expected until 5/30/2024