Erlotinib Hydrochloride, Free Base, EGFR Inhibitor (CP-358774, OSI-774, Ro 50-8231)

Blue Ice

393, 44

Supplied as a white solid.

Erlotinib Hydrochloride is an antineoplastic drug. It regulates mechanistic target of rapamycin (mTOR) inhibition, epidermal growth factor receptor down-regulation and epidermal interstitial transformation (EMT) suppression.

Synonyms:
N-(3-ethynylphenyl)-6, 7-bis(2-methoxyethoxy)-4-quinazolinamine hydrochloride; NSC 718781; CP-358774, OSI-774, Ro 50-8231

CAS No:
183321-74-6

Molecular Formula:
C22H23N3O4

Molecular Weight:
393.44

Purity:
≥95%

Appearance:
White solid

Solubility:
DMF: 50mg/ml
DMF:PBS (pH 7.2) (1:9): 0.1mg/ml
DMSO: 25mg/ml
Ethanol: 0.25mg/ml

Storage and Stability:
Lyophilized and reconstituted products are stable for 6 months after receipt at -20°C. Reconstitute with sterile buffer. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.