Parathyroid hormone, active (PTH), Recombinant, Human, aa32-115

Blue Ice

9, 4

Lyophilized from 0.2um filtered PBS, pH 7.4

PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblastic cells. {ECO:0000269|PubMed:21076856}.

Biological Activity:
Fully biologically active when compared to standard. The ED50 as determined by its ability to induce cAMP accumulation in murine MC3T3E1 cells is less than 50ng/ml, corresponding to a specific activity of ＞ 2.0x10e4 IU/mg.

Sequence:
SVSEIQLMHN LGKHLNSMER VEWLRKKLQD VHNFVALGAP LAPRDAGSQR PRKKEDNVLV ESHEKSLGEA DKADVNVLTK AKSQ

Molecular Weight:
9.4kD

PubMed ID:
6950381; 6220408; 15489334; 7829495; 4833516; 15340161; 4521809; 728431; 1125201; 4474131; 4721748; 21076856; 2069952; 8344299; 7797503; 10623601; 10837469; 18375760; 2212001; 10523031; 18056632

Gene Name:
PTH

Swiss Prot:
P01270

Storage and Stability:
Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.