DR6 (Human):Fc (Human) (Tumor Necrosis Factor Receptor Superfamily Member 21, TNFRSF21, Death Receptor 6, CD358)

Blue Ice

80

Supplied as a lyophilized powder in PBS. Reconstitute witn 50ul sterile ddH2O. PBS containing at least 0.1% BSA should be used for further dilutions.

DR6 is an orphan TNF receptor superfamily member belonging to a subgroup of receptors called death receptors. Expressed ubiquitously with high expression in lymphoid organs, heart, brain, and pancreas. Broadly expressed by developing neurons where it functions as pro-apoptotic factor. Recently, it has been reported that interaction with the beta-amyloid precursor protein (APP) activates a widespread caspase-dependent self-destruction program dependent on caspase-6.

Sequence:
The Fc portion of human IgG1 is fused to the C-terminus of human DR6 (aa 42-351).

Molecular Weight:
~80kD (SDS-PAGE)

Endotoxin:
<0.1EU/ug (LAL test; Lonza).

Storage and Stability:
Lyophilized powder may be stored at -20°C. Stable for 12 months after receipt at -20°C. Reconstitute with sterile buffer or ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.