IL36RN (Interleukin-36 Receptor Antagonist Protein,FIL1 delta,IL-1-Related Protein 3,IL-1RP3,Interleukin-1 HY1,IL-1HY1,Interleukin-1 delta,IL-1 delta,Interleukin-1 Family Member 5,IL-1F5,Interleukin-1 Receptor Antagonist Homolog 1,

Antibodies / Antibodies-Interleukin

-20°C

Supplied as a liquid in PBS, pH 7.3, 0.05% sodium azide.

Synthetic peptide corresponding to human IL36RN.

IL-1 (Interleukin-1) is a cytokine responsible for initiating a variety of activities through the activation of transcription factors, NFkB and AP-1, thereby promoting host response to injury or infection. The IL-1 superfamily is comprised of several ligands and receptors. IL-1F5, also known as IL-1d, IL-1 like protein 1 (IL-1L1), IL-1HY1, IL-1ra (receptor antagonist) homolog 1 or IL-1 related protein 3 (IL-1rp3), is a secreted ligand belonging to this superfamily. IL-1F5 is expressed in monocytes and macrophages and is activated by endotoxins. It shares 47% sequence identity with IL-1ra and similarly lacks the loop between the fourth and fifth ∫-strands. IL-1F5 acts as an antagonist, inhibiting the IL-1F9 activation of NFkB. Similar to other family members, IL-1F5 can be regulated by bacterial lipopolysaccharide (LPS).

Applications:
Suitable for use in Western Blot. Other applications not tested.

Recommended Dilution:
Western Blot: 1:500-1:1000
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.