Neurogenic Locus Notch Homolog Protein 3 (NOTCH3) Antibody

Neurogenic Locus Notch Homolog Protein 3 (NOTCH3)

Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.

NOTCH3 Antibody is a Rabbit Polyclonal antibody against NOTCH3. This gene encodes the third discovered human homologue of the Drosophilia melanogaster type I membrane protein notch. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signalling pathway that plays a key role in neural development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remains to be determined. Mutations in NOTCH3 have been identified as the underlying cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL).

PBS, pH 7.3, containing 0.01% thimerosal, 50% glycerol.

NOTCH3

Purified by affinity chromatography.