ABflo® 647 Rabbit anti-Human Nectin-1/CD111 mAb

ABflo® 647. Ex:656nm. Em:670nm.

Store at 2-8°C. Avoid freeze.|Buffer: PBS with 0.03% proclin300, 0.2% BSA, pH7.3.

This gene encodes an adhesion protein that plays a role in the organization of adherens junctions and tight junctions in epithelial and endothelial cells. The protein is a calcium(2+)-independent cell-cell adhesion molecule that belongs to the immunoglobulin superfamily and has 3 extracellular immunoglobulin-like loops, a single transmembrane domain (in some isoforms), and a cytoplasmic region. This protein acts as a receptor for glycoprotein D (gD) of herpes simplex viruses 1 and 2 (HSV-1, HSV-2), and pseudorabies virus (PRV) and mediates viral entry into epithelial and neuronal cells. Mutations in this gene cause cleft lip and palate/ectodermal dysplasia 1 syndrome (CLPED1) as well as non-syndromic cleft lip with or without cleft palate (CL/P). Alternative splicing results in multiple transcript variants encoding proteins with distinct C-termini.

Recombinant fusion protein containing a sequence corresponding to amino acids 1-334 of human Nectin-1/CD111 (NP_002846.3).

57kDa/51kDa/39kDa

Cell Biology Developmental Biology, Cell Adhesion, Immunology Inflammation, CDs, Neuroscience.

5818

NECTIN1