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Recombinant Saccharomyces cerevisiae Probable tRNA threonylcarbamoyladenosine biosynthesis protein KAE1(KAE1)

Recombinant Saccharomyces cerevisiae Probable tRNA threonylcarbamoyladenosine biosynthesis protein KAE1(KAE1)

ArtNr	CSB-EP330543SVG-50
Hersteller	Cusabio
Menge	50 ug
Quantity options	1 mg 10 ug 100 ug 20 ug 200 ug 50 ug 500 ug
Kategorie	Metabolism Cholesterol & Lipid Metabolism Peptides & Proteins Recombinant Proteins
Typ	Proteins Recombinant
Format	Liquid or Lyophilized powder
Specific against	other
Host	E.coli
Konjugat/Tag	HIS
Purity	Greater than 90% as determined by SDS-PAGE.
Sequence	MVNLNTIPPKNGRDYYIALGLEGSANKLGVGIVKH PLLPKHANSDLSYDCEAEMLSNIRDTYVTPPGEGF LPRDTARHHRNWCIRLIKQALAEADIKSPTLDIDV ICFTKGPGMGAPLHSVVIAARTCSLLWDVPLVGVN HCIGHIEMGREITKAQNPVVLYVSGGNTQVIAYSE KRYRIFGETLDIAIGNCLDRFARTLKIPNEPSPGY NIEQLAKKAPHKENLVELPYTVKGMDLSMSGILAS IDL
Protein Familie	KAE1 / TsaD family
Citations	"Sequencing and comparison of yeast species to identify genes and regulatory elements."Kellis M., Patterson N., Endrizzi M., Birren B.W., Lander E.S.Nature 423:241-254(2003)
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	Kinase-associated endopeptidase 1; N6-L-threonylcarbamoyladenine synthase; Short name:; t(6)A synthase; t(6)A37 threonylcarbamoyladenosine biosynthesis protein KAE1; tRNA threonylcarbamoyladenosine biosynthesis protein KAE1
Lieferbar
Manufacturer - Conjugate / Tag	N-terminal 6xHis-tagged
Storage Conditions	The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20C/-80C. The shelf life of lyophilized form is 12 months at -20C/-80C.
Molecular Weight	46.7 kDa
Relevance	Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t6A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. KAE1 likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators.
Expression Region	1-386aa
Notes	Repeated freezing and thawing is not recommended. Store working aliquots at 4C for up to one week.
Function	Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. KAE1 likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators.
Subcellular Location	Cytoplasm, Nucleus
Gene Names	KAE1
Sequence Info	Full Length
Organism	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Storage Buffer	Tris-based buffer, 50% glycerol

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CSB-EP330543SVG-50-datasheet.pdf

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Menge: 50 ug

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Lieferung vsl. bis 28.08.2025

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