CD59 Glycoprotein (CD59) Antibody

CD59 Glycoprotein (CD59)

Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.

CD59 Antibody is a Rabbit Polyclonal antibody against CD59. This gene encodes a cell surface glycoprotein that regulates complement-mediated cell lysis, and it is involved in lymphocyte signal transduction. This protein is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during the assembly of this complex, thereby inhibiting the incorporation of multiple copies of C9 into the complex, which is necessary for osmolytic pore formation. This protein also plays a role in signal transduction pathways in the activation of T cells. Mutations in this gene cause CD59 deficiency, a disease resulting in hemolytic anemia and thrombosis, and which causes cerebral infarction. Multiple alternatively spliced transcript variants, which encode the same protein, have been identified for this gene. [provided by RefSeq, Jul 2008].

PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol.

CD59

Purified by affinity chromatography.