Protein Tyrosine Phosphatase, Non Receptor Type 5 (PTPN5) Antibody

Protein Tyrosine Phosphatase, Non Receptor Type 5 (PTPN5)

Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.

STEP (Protein-tyrosine phosphatase striatum-enriched) is a neural-specific protein-tyrosine phosphatase. It is also known as PTPN5 (tyrosine-protein phosphatase, non-receptor type 5). STEP immunoreactive areas are most intense in the regions of the CNS receiving a dopaminergic input (e.g. striatum, basal ganglia). STEP is part of the NMDA receptor (R) complex and inhibits NMDAR single-channel activity and NMDAR-mediated synaptic current. Phosphorylation of STEP, via D1 and PKA activation by dopamine, decreases the activity of STEP by reducing its affinity for substrate.

PBS containing 0.09% sodium azide.

This product is for research use only.

PTN5_HUMAN