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Mouse Irf3 Antibody

Mouse Irf3 Antibody

Manufacturer	Abbexa
Category	Antibodies Western Blot Primary Antibodies
Type	Antibody Primary
Specific against	Mouse
Isotype	IgG
Applications	WB
Amount	80 ul
Host	Rabbit
Item no.	abx031370-80
Conjugate/Tag	Unconjugated
eClass 6.1	32160702
eClass 9.0	32160702
Available
Antigen	Mouse Irf3
Description	Mediates interferon-stimulated response element (ISRE) promoter activation. Functions as a molecular switch for antiviral activity. DsRNA generated during the course of an viral infection leads to IRF3 phosphorylation on the C-terminal serine/threonine cluster. This induces a conformational change, leading to its dimerization, nuclear localization and association with CREB binding protein (CREBBP) to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of genes under the control of ISRE. The complex binds to the IE and PRDIII regions on the IFN-alpha and IFN-beta promoters respectively. IRF-3 does not have any transcription activation domains (By similarity).
Conjugation	Unconjugated
Purification	Purified through a protein A column, followed by peptide affinity purification.
Storage	Aliquot and store at -20C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P70671
UniProt Entry Name	IRF3_MOUSE
Buffer	PBS containing 0.09% sodium azide.
Dry Ice	No
Note	This product is for research use only.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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