DYRK1A

Manufacturer	Abclonal
Type	Antibody Polyclonal
Specific against	Human
Applications	WB
Protein Family	Neuroscience
Amount	100ug
Host	Rabbit
Item no.	A0595
eClass 6.1	32160702
eClass 9.0	32160702
Available
*	DESCRIPTION
Calculated MW	86kDa
Immunogen	A synthetic peptide of human DYRK1A
Gene ID	1859
Swiss Prot	Q13627
Synonyms	MNB; DYRK; HP86; MNBH; MRD7; DYRK1;
Isotype	IgG
Purity	Affinity purification
Storage Buffer	Store at 4? or -20?. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Background	This gene encodes a member of the Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. This member contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-consecutive-histidine repeat. It catalyzes its autophosphorylation on serine/threonine and tyrosine residues. It may play a significant role in a signaling pathway regulating cell proliferation and may be involved in brain development. This gene is a homolog of Drosophila mnb (minibrain) gene and rat Dyrk gene. It is localized in the Down syndrome critical region of chromosome 21, and is considered to be a strong candidate gene for learning defects associated with Down syndrome. Alternative splicing of this gene generates several transcript variants differing from each other either in the 5' UTR or in the 3' coding region. These variants encode at least five different isoforms.
Recommended Dilutions	WB 1:500-1:1000
illustration	Western blot analysis of extracts of mouseliver cell lines, using DYRK1A antibody.

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