Phospho-STAT6-Y641 Rabbit pAb

Phosphorylated Antibodies

Store at -20°C. Avoid freeze / thaw cycles.|Buffer: PBS with 0.05% proclin300, 50% glycerol, pH7.3.

The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants.

A synthetic phosphorylated peptide around Y641 of human STAT6 (NP_003144.3).

94kDa

Epigenetics Nuclear Signaling, Transcription Factors, Protein phosphorylation, Signal Transduction, Immunology Inflammation, Jak-Stat-IL-6 Receptor Signaling Pathway.

6778

STAT6