Mre11

Manufacturer	Abclonal
Type	Antibody Polyclonal
Specific against	Human, Mouse, Rat
Applications	WB, IHC
Protein Family	Cell Cycle
Amount	200ug
Host	Rabbit
Item no.	A0109-200ug
eClass 6.1	32160702
eClass 9.0	32160702
Available
*	DESCRIPTION
Calculated MW	81kDa
Immunogen	Recombinant protein of human MRE11A
Gene ID	4361
Swiss Prot	P49959
Synonyms	ATLD; HNGS1; MRE11; MRE11B;
Isotype	IgG
Purity	Affinity purification
Storage Buffer	Store at -20? or -80?. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Background	This gene encodes a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. By itself, the protein has 3' to 5' exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog; this complex is required for nonhomologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3' to 5' exonuclease activities. In conjunction with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. This gene has a pseudogene on chromosome 3. Alternative splicing of this gene results in two transcript variants encoding different isoforms.?
Recommended Dilutions	WB 1:500-1:2000 IHC 1:50-1:200
illustration	Western blot analysis of extracts of A431 cellline, using MRE11A antibody.

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Amount: 200ug

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Delivery expected until 7/2/2024