GSTP1

Manufacturer	Abclonal
Type	Antibody Polyclonal
Specific against	Human, Mouse, Rat
Applications	WB, IHC
Protein Family	MAPK Signaling
Amount	100ug
Host	Rabbit
Item no.	A0347
eClass 6.1	32160702
eClass 9.0	32160702
Available
*	DESCRIPTION
Calculated MW	23kDa
Immunogen	Fusion protein of human GSTP1
Gene ID	2950
Swiss Prot	P09211
Synonyms	GSTP1; DFN7; FAEES3; GST3; PI ;
Isotype	IgG
Purity	Affinity purification
Storage Buffer	Store at -20? or -80?. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Background	Glutathione S-transferases (GSTs) are a family of isoenzymes that detoxify electrophiles through conjugation to thiol-reduced glutathione (GSH). Thus, they are critical in protecting cells from toxins (drugs, pesticides, carcinogens) and oxidative stress (1). Eight isoforms of cytosolic-soluble GSTs (?, ?, ?, ?, ?, ?, ?, and ?) are identified, while only GST-?, -?, and -? are described in the central nervous system (2). GSTP1 (GST?) is overexpressed in early stages of carcinogenesis and can be used as a neoplastic marker in tumor tissues (3). GSTP1 directly inhibits TRAF2 and JNK but not NF-?B (4, 5). Corresponding GSTP1 gene polymorphisms affect substrate selectivity and stability, and the oxidative milieu in dopaminergic neurons, which increases the susceptibility to Parkinson’s disease (6).
Recommended Dilutions	WB 1:500-1:1000 IHC 1:50-1:100
illustration	Western blot analysis of extracts of Jurkat cellusing GSTP1antibody.

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