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Survivin(BIRC5)

Survivin(BIRC5)

Manufacturer	Abclonal
Type	Antibody Polyclonal
Specific against	Human, Mouse, Rat
Applications	WB, IHC
Protein Family	Apoptosis/Autophagy
Amount	100ug
Host	Rabbit
Item no.	A0350
eClass 6.1	32160702
eClass 9.0	32160702
Available
*	DESCRIPTION
Calculated MW	16kDa
Immunogen	Fusion protein of human BIRC5
Gene ID	332
Swiss Prot	O15392
Synonyms	BIRC5; API4; EPR-1; SURVIVIN; Survivin;
Isotype	IgG
Purity	Affinity purification
Storage Buffer	Store at -20? or -80?. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Background	Survivin is a 16 kDa anti-apoptotic protein highly expressed during fetal development and cancer cell malignancy (1). Survivin binds and inhibits caspase-3, controlling the checkpoint in the G2/M-phase of the cell cycle by inhibiting apoptosis and promoting cell division (2, 3). This regulatory process requires the phosphorylation of survivin at Thr34 by p34 cdc2 kinase (4). Gene targeting using a Thr34 phosphorylation-defective survivin mutant, as well as antisense survivin, have been shown to inhibit tumor growth (5, 6).
Recommended Dilutions	WB 1:500-1:1000 IHC 1:50-1:100
illustration	Western blot analysis of PC-3 cell lysate using BIRC5 antibody.

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