EPOR Rabbit pAb

Polyclonal Antibodies

Store at -20°C. Avoid freeze / thaw cycles.|Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

This gene encodes the erythropoietin receptor which is a member of the cytokine receptor family. Upon erythropoietin binding, this receptor activates Jak2 tyrosine kinase which activates different intracellular pathways including: Ras/MAP kinase, phosphatidylinositol 3-kinase and STAT transcription factors. The stimulated erythropoietin receptor appears to have a role in erythroid cell survival. Defects in the erythropoietin receptor may produce erythroleukemia and familial erythrocytosis. Dysregulation of this gene may affect the growth of certain tumors. Alternate splicing results in multiple transcript variants.

A synthetic peptide corresponding to a sequence within amino acids 274-508 of human EPOR (NP_000112.1).

55kDa

Signal Transduction, G protein signaling, Small G proteins, Cell Biology Developmental Biology, Apoptosis, Immunology Inflammation, Stem Cells, Hematopoietic Progenitors, Cardiovascular, Angiogenesis, Heart, Hypertrophy.

2057

EPOR