LIMK1 Rabbit pAb

Polyclonal Antibodies

Store at -20°C. Avoid freeze / thaw cycles.|Buffer: PBS with 0.05% proclin300, 50% glycerol, pH7.3.

There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. LIMK1 is a serine/threonine kinase that regulates actin polymerization via phosphorylation and inactivation of the actin binding factor cofilin. This protein is ubiquitously expressed during development and plays a role in many cellular processes associated with cytoskeletal structure. This protein also stimulates axon growth and may play a role in brain development. LIMK1 hemizygosity is implicated in the impaired visuospatial constructive cognition of Williams syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Recombinant fusion protein containing a sequence corresponding to amino acids 510-647 of LIMK1 (NP_002305.1).

73kDa

Signal Transduction, Kinase, Serine threonine kinases, Tyrosine kinases, Cell Biology Developmental Biology, Cytoskeleton, Microfilaments, Microtubules, Actins, TGF-b-Smad Signaling Pathway, Immunology Inflammation, Neuroscience, Cell Type Marker, Neuron marker.

3984

LIMK1