Anti-GLUT1 (extracellular)-APC Antibody

Antibodies

Antibodies

Allophycocyanin (APC)

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

Lyophilized powder

Glucose transporter 1, Facilitated glucose transporter member 1, SLC2A1, DYT9 - A Rabbit Polyclonal Antibody to GLUT1 (extracellular) conjugated to the fluorescent dye Allophycocyanin (APC)

Not recommended for mouse and rat samples

Confirmed by amino acid analysis and mass spectrometry

1 mg/ml

1st extracellular loop

Rat

41116161

Glucose transporter 1 (GLUT1) belongs to the major facilitator superfamily (MFS). It is encoded by SLC2A1, and mediates basal-level cellular uptake of glucose into many tissues. GLUT1 contains 12 membrane-spanning domains with both the amino and carboxyl termini oriented intracellularly. In addition, a single extracellular N-linked glycosylation site is present1.GLUT1 is widely expressed, but it is most abundant in fibroblasts, erythrocytes, and endothelial cells with low levels of expression in muscle, liver, and adipose tissue2.Inactivating mutations of GLUT1, resulting in compromised transport activities for glucose, are associated with diseases as a result of lack of energy supply to the brain3. GLUT1 deficiency syndrome (also known as De Vivo syndrome) is characterized by a spectrum of symptoms including early-onset seizures, microcephaly and retarded development4. In addition, elevated expression levels of GLUT1 have been observed in several cancer types, identifying GLUT1 as an important prognostic indicator for tumorigenesis5.