Anti-Human GLUT3 (extracellular)-PE Antibody

FC, LCI

Glucose transporter 3, Facilitated glucose transporter member 3, SLC2A3

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

Lyophilized powder

Polyclonal

Western blot analysis (unlabeled antibody, #AGT-043), and direct flow cytometry (labeled antibody).

15 µl or 50 µl double distilled water (DDW), depending on the sample size.

1% BSA, 0.05% NaN3

SLC2A3

Human

41116161

The GLUT protein family is encoded by the SLC2 genes and is a member of the major facilitator superfamily of membrane transporters. GLUTs are recognized as key regulators of whole-body glucose homeostasis, and are responsible for the uptake of carbohydrate-derived glucose by cells. There are 14 GLUT isoforms divided into 3 different group classes based on sequence similarity and structural and functional characteristics1, 2.GLUT3 is a low-Km protein responsible for glucose uptake into neurons. It is predominantly expressed in neurons and is commonly called "neuronal glucose transporter". The protein contains 12 membrane-spanning domains, an N-linked glycosylation site in loop 1 responsible for high-affinity transport of glucose, and intracellular NH2- and COOH- termini. In addition, there are several conserved residues and motifs designated "sugar transporter signatures"1, 2.GLUT3 levels are high in some malignant glioma cells compared to normal glial cells and therefore may be used as a therapeutic target in some cancer treatment3.