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Anti-IL23 Receptor/Il23r Antibody Picoband®

Anti-IL23 Receptor/Il23r Antibody Picoband®

Item no.	BOS-A00607-1-APC
Manufacturer	Boster
Amount	100 ug
Quantity options	100 ug/vial 10 ug 100 ug 100 ug 100 ug 100 ug 100 ug 100 ug 100 ug 100 ug 100 ug 100 ug
Category	Oncology Neuroscience Neural Lineage Markers Neural Transcription Factors Antibodies Cell Biology Cell Culture Cytokines Western Blot ELISA Primary Antibodies By Organ Bladder Cancer Immunostaining
Type	Antibody Polyclonal
Format	Lyophilized
Applications	WB, ELISA
Specific against	Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host	Rabbit
Isotype	IgG
Conjugate/Tag	APC
Citations	1. Duerr RH, Taylor KD, Brant SR, Rioux JD, Silverberg MS, Daly MJ, et al. (Dec 2006). A genome-wide association study identifies IL23R as an inflammatory bowel disease gene. Science. 314 (5804): 1461–3. 2. Momozawa Y, Mni M, Nakamura K, Coppieters W, Almer S, Amininejad L, et al. (Jan 2011). Resequencing of positional candidates identifies low frequency IL23R coding variants protecting against inflammatory bowel disease. Nature Genetics. 43 (1): 43–7.
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Interleukin-23 receptor,IL-23 receptor,IL-23R,Il23r
Available
Manufacturer - Applications	ELISA (Cap), WB
Manufacturer - Category	Primary Antibodies
Storage Conditions	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
Observed Molecular weight	58 kDa
Clonality	Polyclonal
Application Details	Western blot, 0.1-0.5μg/ml ELISA (Cap), 1-5μg/ml
Gene Name	Il23r
Gene Full Name	interleukin 23 receptor
Manufacturer - Specificity	No cross reactivity with other proteins.
Background	Interleukin 23 receptor is a type I cytokine receptor. IL23R is its human gene. The protein encoded by this gene is a subunit of the receptor for IL23A/IL23. This protein pairs with the receptor molecule IL12RB1/IL12Rbeta1, and both are required for IL23A signaling. This protein associates constitutively with Janus kinase 2 (JAK2), and also binds to transcription activator STAT3 in a ligand-dependent manner.
Immunogen	E. coli-derived mouse IL23 Receptor recombinant protein (Position: I25-D233).
Contents	Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
Purification	Immunogen affinity purified.
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.
Manufacturer - Research Category	Cell Type Markers, Cytokines, Epigenetics and Nuclear Signaling, Immunoglobulins, Immunology, Innate Immunity, Interleukins, Nuclear Signaling, Nuclear Signaling Pathways, Receptors, Signal Transduction, Signaling Pathway
Protein Function	Associates with IL12RB1 to form the interleukin-23 receptor. Binds IL23 and mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade. IL23 functions in innate and adaptive immunity and may participate in acute response to infection in peripheral tissues. IL23 may be responsible for autoimmune inflammatory diseases and be important for tumorigenesis (By similarity).
Subcellular Localization	Cell membrane; Single-pass type I membrane protein.
Description	Boster Bio Anti-IL23 Receptor/Il23r Antibody Picoband® catalog # A00607-1. Tested in ELISA, WB applications. This antibody reacts with Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Tissue Specificity	Expressed by Th1, Th2 and dendritic cells.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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BOS-A00607-1-APC-datasheet.pdf

BOS-A00607-1-APC-safety-datasheet.pdf