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Anti-IL8/CXCL8 Antibody Picoband®

Anti-IL8/CXCL8 Antibody Picoband®

Item no.	BOS-PA1353-PE
Manufacturer	Boster
Amount	100 ug
Quantity options	100 ug/vial 10 ug 100 ug 100 ug 100 ug 100 ug 100 ug 100 ug 100 ug 100 ug 100 ug 100 ug 100 ug
Category	Oncology Neuroscience Neuroinflammation Metabolism Diabetes Neural Signaling Antibodies By Cell Type Carcinoma Immunohistochemistry Western Blot Primary Antibodies By Organ Lung Cancer
Type	Antibody Polyclonal
Format	Lyophilized
Applications	WB, IHC
Specific against	Human (Homo sapiens)
Host	Rabbit
Isotype	IgG
Conjugate/Tag	PE
Sensitivity	>5000 cells
Sequence	Belongs to the intercrine alpha (chemokine CxC) family.
Citations	1. Wolff B, Burns AR, Middleton J, Rot A (November 1998). Endothelial cell memory of inflammatory stimulation: human venular endothelial cells store interleukin 8 in Weibel-Palade bodies. 2. Utgaard JO, Jahnsen FL, Bakka A, Brandtzaeg P, Haraldsen G (November 1998). Rapid secretion of prestored interleukin 8 from Weibel-Palade bodies of microvascular endothelial cells. 3. Modi WS, Dean M, Seuanez HN, Mukaida N, Matsushima K, O'Brien SJ (January 1990). Monocyte-derived neutrophil chemotactic factor (MDNCF/IL-8) resides in a gene cluster along with several other members of the platelet factor 4 gene superfamily. 4. Entrez Gene: IL8 interleukin 8. 5. Köhidai L, Csaba G (July 1998). Chemotaxis and chemotactic selection induced with cytokines (IL-8, RANTES and TNF-alpha) in the unicellular Tetrahymena pyriformis. 6. O'Donovan, N., Galvin, M., Morgan, J. G. Physical mapping of the CXC chemokine locus on human chromosome 4. Cytogenet.
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Interleukin-8,IL-8,C-X-C motif chemokine 8,Chemokine (C-X-C motif) ligand 8,Emoctakin,Granulocyte chemotactic protein 1,GCP-1,Monocyte-derived neutrophil chemotactic factor,MDNCF,Monocyte-derived neutrophil-activating peptide,MONAP,Neutrophil-activating protein 1,NAP-1,Protein 3-10C,T-cell chemotactic factor,MDNCF-a,GCP/IL-8 protein IV,IL8/NAP1 form I,Interleukin-8,(Ala-IL-8)77,GCP/IL-8 protein II,IL-8 (1-77),IL8/NAP1 form II,MDNCF-b,IL-8 (5-77),IL-8 (6-77),(Ser-IL-8)72,GCP/IL-8 protein I,IL8/NAP1 form III,Lymphocyte-derived neutrophil-activating factor,LYNAP,MDNCF-c,Neutrophil-activating factor,NAF,IL-8 (7-77),GCP/IL-8 protein V,IL8/NAP1 form IV,IL-8 (8-77),GCP/IL-8 protein VI,IL8/NAP1 form V,IL-8 (9-77),GCP/IL-8 protein III,IL8/NAP1 form VI,CXCL8,IL8
Available
Manufacturer - Category	Primary Antibodies
Storage Conditions	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
Observed Molecular weight	60 kDa
Calculated Molecular weight	11098 MW
Clonality	Polyclonal
Application Details	Western blot, 0.1-0.5μg/ml, Human Immunohistochemistry (Paraffin-embedded Section), 2-5μg/ml, Human
Gene Name	IL8
Gene Full Name	Interleukin-8
Manufacturer - Specificity	No cross reactivity with other proteins.
Background	Interleukin-8 (IL-8) is a chemokine produced by macrophages and other cell types such as epithelial cells. It is also synthesized by endothelial cells, which store IL-8 in their storage vesicles, the Weibel-Palade bodies. In humans, the interleukin-8 protein is encoded by the IL8 gene. Interleukin-8 (IL8) is a member of the CXC chemokine family (Hull et al., 2001). IL-8 is believed to play a role in the pathogenesis of bronchiolitis, a common respiratory tract disease caused by viral infection. This gene and other ten members of the CXC chemokine gene family form a chemokine gene cluster in a region mapped to chromosome 4q. The genes for IL8 have been co-localized on a 335-kb genomic fragment.
Immunogen	A synthetic peptide corresponding to a sequence at the C-terminus of human IL8.
Contents	Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.
Purification	Immunogen affinity purified.
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.
Manufacturer - Research Category	Angiogenesis, Cancer, Cardiovascular, Cytokines, Immunology, Innate Immunity, Interleukins, Invasion/Microenvironment
Protein Name	Interleukin-8(IL-8)
Protein Function	IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus. IL-8 (6-77) has a 5-10-fold higher activity on neutrophil activation, IL-8 (5-77) has increased activity on neutrophil activation and IL-8 (7-77) has a higher affinity to receptors CXCR1 and CXCR2 as compared to IL-8 (1-77), respectively.
Subcellular Localization	Secreted.
Description	Boster Bio Anti-IL8/CXCL8 Antibody catalog # PA1353. Tested in IHC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Tissue Specificity	Widely expressed; lower levels in brain and lung.
Sequence Similarities	Belongs to the intercrine alpha (chemokine CxC) family.
Manufacturer - Alias	Interleukin-8, IL-8, C-X-C motif chemokine 8, Chemokine (C-X-C motif) ligand 8, Emoctakin, Granulocyte chemotactic protein 1, GCP-1, Monocyte-derived neutrophil chemotactic factor, MDNCF, Monocyte-derived neutrophil-activating peptide, MONAP, Neutrophil-activating protein 1, NAP-1, Protein 3-10C, T-cell chemotactic factor, MDNCF-a, GCP/IL-8 protein IV, IL8/NAP1 form I, Interleukin-8, (Ala-IL-8)77, GCP/IL-8 protein II, IL-8 (1-77), IL8/NAP1 form II, MDNCF-b, IL-8 (5-77), IL-8 (6-77), (Ser-IL-8)72, GCP/IL-8 protein I, IL8/NAP1 form III, Lymphocyte-derived neutrophil-activating factor, LYNAP, MDNCF-c, Neutrophil-activating factor, NAF, IL-8 (7-77), GCP/IL-8 protein V, IL8/NAP1 form IV, IL-8 (8-77), GCP/IL-8 protein VI, IL8/NAP1 form V, IL-8 (9-77), GCP/IL-8 protein III, IL8/NAP1 form VI, CXCL8, IL8
Manufacturer - Cross Reactivity	No cross-reactivity with other proteins

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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BOS-PA1353-PE-datasheet.pdf

BOS-PA1353-PE-safety-datasheet.pdf