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Anti-SIRPa(DM8) antibody; Rabbit mAb

Anti-SIRPa(DM8) antibody; Rabbit mAb

Item no.	DIM-DME100008-100ug
Manufacturer	DIMA Biotechnology
Amount	100 ug
Quantity options	100 ug 100 uL 10 ug 10 ul 500 ug
Category	Oncology Neuroscience Molecular Targets for Neuroscience Aging & Neurological Disorders Protein Aggregation, Clearance & Misfolding Antibodies By Cell Type Carcinoma Flow Cytometry Immunoprecipitation ELISA Immunofluorescence Primary Antibodies
Type	Antibody Monoclonal
Format	Lyophilized
Applications	FC, IF, IP, ELISA
Clone	DM8
Specific against	Human (Homo sapiens)
Host	Rabbit
Isotype	IgG
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	BIT,CD172a,MFR,MYD-1,P84,PTPNS1,SHPS-1,SHPS1,SIRP,SIRP-ALPHA-1,SIRPalpha,SIRPalpha2
Similar products	CD172a, MFR, BIT, MYD-1, P84, PTPNS1, SHPS-1, SHPS1, SIRP, SIRP-ALPHA-1, SIRPalpha, SIRPalpha2
Shipping Condition	Room temperature
Available
Manufacturer - Category	Monoclonal antibodies
Manufacturer - Targets	SIRPa
Molecular Weight	66.9kDa (predicted)
Buffer	Preservative: 0.1% Procline 300 Constituents: 50% Glycerol; PBS, pH 7.4; 0.1% BSA
Clonality	Monoclonal
Purification	Purified from cell culture supernatant by affinity chromatography
Recommended Dilutions	Flow Cyt 1:100; IP 1:30
Storage	Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
Background	The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family; and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein can be phosphorylated by tyrosine kinases. The phospho-tyrosine residues of this PTP have been shown to recruit SH2 domain containing tyrosine phosphatases (PTP); and serve as substrates of PTPs. This protein was found to participate in signal transduction mediated by various growth factor receptors. CD47 has been demonstrated to be a ligand for this receptor protein. This gene and its product share very high similarity with several other members of the SIRP family. These related genes are located in close proximity to each other on chromosome 20p13. Multiple alternatively spliced transcript variants have been determined for this gene. [provided by RefSeq; Jul 2008]
Immunogen	Recombinant human SIRPalpha (Glu31-Arg370) produced by using human HEK293 cells
Description	Anti-SIRPa(DM8) antibody; Rabbit mAb
Formulation & Reconstitution	Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution.
Usage	Research use only

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100 ug

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Delivery expected until 10/30/2025

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