Comparison

Biotinylated Anti-CS1 antibody(DM11),Rabbit mAb

Item no. DIM-DME100011B-10ug
Manufacturer DIMA Biotechnology
Amount 10 ug
Quantity options 100 ug 10 ug 500 ug
Category
Type Antibody Monoclonal
Format Lyophilized
Applications FC, ELISA
Clone DM11
Specific against Human (Homo sapiens)
Host Rabbit
Isotype IgG
ECLASS 10.1 42030590
ECLASS 11.0 42030590
UNSPSC 12352203
Alias SLAM7 (19A,CD319,CRACC,CS1)
Shipping Condition Room temperature
Available
Manufacturer - Category
Monoclonal antibodies
Manufacturer - Targets
CS1
Clonality
Monoclonal
Purification
Purified from cell culture supernatant by affinity chromatography
Recommended Dilutions
Flow Cyt 1:100
Storage
Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
Background
Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins; SH2D1A:SAP and:or SH2D1B:EAT-2. Isoform 1 mediates NK cell activation through a SH2D1A-independent extracellular signal-regulated ERK-mediated pathway (PubMed:11698418). Positively regulates NK cell functions by a mechanism dependent on phosphorylated SH2D1B. Downstream signaling implicates PLCG1; PLCG2 and PI3K (PubMed:16339536). In addition to heterotypic NK cells-target cells interactions also homotypic interactions between NK cells may contribute to activation. However; in the absence of SH2D1B; inhibits NK cell function. Acts also inhibitory in T-cells (By similarity). May play a role in lymphocyte adhesion (PubMed:11802771). In LPS-activated monocytes negatively regulates production of proinflammatory cytokines (PubMed:23695528).
Description
Biotinylated Anti-CS1 antibody(DM11), Rabbit mAb
Formulation & Reconstitution
Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution.
Usage
Research use only

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Amount: 10 ug
Available: In stock
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