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MYLIP Antibody

MYLIP Antibody

Item no.	OACA08781
Manufacturer	AVIVA Systems Biology
Amount	50 ul
Category	Neuroscience Metabolism Cholesterol & Lipid Metabolism Molecular Targets for Neuroscience Targets for Rodent Neurosciences Neural Signaling Antibodies Obesity Immunohistochemistry ELISA Lipoprotein Receptors & Associated Proteins Primary Antibodies Immunostaining
Type	Antibody Polyclonal
Format	Liquid
Applications	IHC, ELISA
Specific against	Human (Homo sapiens)
Host	Rabbit
Isotype	IgG
Conjugate/Tag	Unconjugated
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	band 4.1 superfamily member BZF1;cellular modulator of immune recognition (c-MIR);E3 ubiquitin ligase-inducible degrader of the low density lipoprotein receptor;E3 ubiquitin-protein ligase MYLIP;IDOL;inducible degrader of the LDL-receptor;MIR;Myosin regulatory light chain interacting protein;RING-type E3 ubiquitin transferase MYLIP.
Shipping Condition	Cool pack
Available
Manufacturer - Type	Polyclonal Antibody
Manufacturer - Category	Root Catalog/Products/Polyclonal Antibodies, Root Catalog/Products/Primary Antibodies
Shipping Temperature	Wet Ice
Manufacturer - Application Additional Information	IHC: 1:20~200
Gene symbol	MYLIP
Gene Fullname	myosin regulatory light chain interacting protein
Product format	Liquid
Reconstitution and storage	-20°C or -80°C
Description of target	E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of myosin regulatory light chain (MRLC), LDLR, VLDLR and LRP8. Activity depends on E2 enzymes of the UBE2D family. Proteasomal degradation of MRLC leads to inhibit neurite outgrowth in presence of NGF by counteracting the stabilization of MRLC by saposin-like protein (CNPY2/MSAP) and reducing CNPY2-stimulated neurite outgrowth. Acts as a sterol-dependent inhibitor of cellular cholesterol uptake by mediating ubiquitination and subsequent degradation of LDLR.
Nucleotide accession_num	NM_013262
Protein accession_num	NP_037394
Protein name	E3 ubiquitin-protein ligase MYLIP
Clonality	Polyclonal
Purification	Affinity Purified
Immunogen	Recombinant Human E3 ubiquitin-protein ligase MYLIP protein (266-445AA)
Formulation	PBS with, 50% glycerol, pH7.3.
Concentration	Varies by lot. See vial for concentration.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 50 ul

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Delivery expected until 10/30/2025

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