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SELL Antibody

SELL Antibody

Item no.	OAEE00293
Manufacturer	AVIVA Systems Biology
Amount	0.1 mg (C100)
Category	Neuroscience Neural Signaling Neural Adhesion Molecules Antibodies Cell Biology Cell Movement Cell Adhesion Flow Cytometry Immunohistochemistry Immunoprecipitation Immunocytochemistry Primary Antibodies Immunochemistry Functional Assays
Type	Antibody Monoclonal
Applications	FC, IP, IHC, ICC, FA
Clone	MEL-14
Specific against	Mouse (Murine, Mus musculus)
Host	Rat
Isotype	IgG2a
Purity	> 95% (by SDS-PAGE)
Citations	Richards H, Longhi MP, Wright K, Gallimore A, Ager A: CD62L (L-selectin) down-regulation does not affect memory T cell distribution but failure to shed compromises anti-viral immunity. J Immunol. 2008 Jan 1;180(1):198-206. Friedline RH, Wong CP, Steeber DA, Tedder TF, Tisch R: L-selectin is not required for T cell-mediated autoimmune diabetes. J Immunol. 2002 Mar 15;168(6):2659-66. Xu H, Manivannan A, Crane I, Dawson R, Liversidge J: Critical but divergent roles for CD62L and CD44 in directing blood monocyte trafficking in vivo during inflammation. Blood. 2008 Aug 15;112(4):1166-74. Chen BJ, Cui X, Sempowski GD, Liu C, Chao NJ: Transfer of allogeneic CD62L- memory T cells without graft-versus-host disease. Blood. 2004 Feb 15;103(4):1534-41. Chin CS, Miller CH, Graham L, Parviz M, Zacur S, Patel B, Duong A, Bear HD: Bryostatin 1/ionomycin (B/I) ex vivo stimulation preferentially activates L-selectinlow tumor-sensitized lymphocytes. Int Immunol. 2004 Sep;16(9):1283-94. Pop SM, Wong CP, He Q, Wang Y, Wallet MA, Goudy KS, Tisch R: The type and frequency of immunoregulatory CD4+ T-cells govern the efficacy of antigen-specific immunotherapy in nonobese diabetic mice. Diabetes. 2007 May;56(5):1395-402. Mannering SI, Cheers C: Interleukin-2 and loss of immunity in experimental Mycobacterium avium infection. Infect Immun. 2002 Jan;70(1):27-35. ten Bruggencate SJ, Hillyer LM, Woodward BD: The proportion of CD45RA(+)CD62L(+) (quiescent-phenotype) T cells within the CD8(+) subset increases in advanced weight loss in the protein- or energy-deficient weanling mouse. J Nutr. 2001 Dec;131(12):3266-9. Fisson S, Darrasse-Jèze G, Litvinova E, Septier F, Klatzmann D, Liblau R, Salomon BL: Continuous activation of autoreactive CD4+ CD25+ regulatory T cells in the steady state. J Exp Med. 2003 Sep 1;198(5):737-46. Brawand P, Cerottini JC, MacDonald HR: Hierarchal utilization of different T-cell receptor Vbeta gene segments in the CD8(+)-T-cell response to an immunodominant Moloney leukemia virus-encoded epitope in vivo. J Virol. 1999 Nov;73(11):9161-9. Gallatin WM, Weissman IL, Butcher EC: A cell-surface molecule involved in organ-specific homing of lymphocytes. Nature 1983 Jul 7;304:30-34.
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	AI528707;CD62;CD62 antigen-like family member L;CD62L;L;LAM-1;LECAM;LECAM1;LECAM-1;leukocyte adhesion molecule 1;leukocyte-endothelial cell adhesion molecule 1;Lnhr;L-sel;L-selectin;Ly-2;Ly-22;Lya;Lyam;Lyam1;Lyam-1;Ly-m2;Ly-m22;lymph node homing receptor;lymphocyte antigen 22;lymphocyte surface MEL-14 antigen.
Shipping Condition	Cool pack
Available
Manufacturer - Type	Monoclonal Antibody
Manufacturer - Applications	Flow cytometry\|Functional assay\|Immunocytochemistry\|Immunohistochemistry-Frozen\|Immunohistochemistry-Paraffin\|Immunoprecipitation
Manufacturer - Category	Root Catalog/Products/Monoclonal Antibodies, Root Catalog/Products/Primary Antibodies
Shipping Temperature	Wet Ice
Gene symbol	Sell
Gene Fullname	selectin, lymphocyte
Product format	Phosphate buffered saline (PBS), pH 7.4
Reconstitution and storage	2°C to 8°C
Description of target	Calcium-dependent lectin that mediates cell adhesion by binding to glycoproteins on neighboring cells. Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia.
Nucleotide accession_num	NM_000655.4
Protein accession_num	NP_000646.2
Protein name	L-selectin
Clonality	Monoclonal
Purification	Purified
Immunogen	C3H/eb mouse B cell lymphoma 38C-13
Manufacturer - Specificity	The rat monoclonal antibody MEL-14 reacts with mouse CD62L (L-selectin), a 75 kDa single chain type I glycoprotein expressed on most peripheral blood B lymphocytes, T lymphocytes, monocytes and granulocytes; it is also present on a subset of NK cells and certain hematopoietic malignant cells.
Formulation	Low endotoxin
Concentration	1 mg/ml
Storage Buffer	Azide free phosphate buffered saline (PBS), approx. pH 7.4; 0.2 um filter sterilized. Endotoxin level is less than 0.01 EU/ug of the protein, as determined by the LAL test.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 0.1 mg (C100)

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