MT1-MMP Antibody

Blue Ice

Observed: 46-70kDa

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. This protein activates MMP2 protein, and this activity may be involved in tumor invasion.

None

THP-1

Mouse liver

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Recombinant protein of human MT1-MMP

matrix metallopeptidase 14 (membrane-inserted)

Optimal dilutions for each application to be determined by the researcher.