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CAST Antibody, KO Validated

CAST Antibody, KO Validated

Item no.	PRS-23-067-100uL
Manufacturer	ProSci
Amount	100 uL
Quantity options	100 uL
Category	Neuroscience Molecular Targets for Neuroscience Antibodies Cell Biology Cell Status Apoptosis Western Blot Primary Antibodies
Type	Antibody Primary
Format	Liquid
Applications	WB
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus)
Host	Rabbit
Isotype	IgG
Conjugate/Tag	Unconjugated
NCBI	CAST
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Calpastatin,Calpain inhibitor,BS-17,Calpastatin
Shipping Condition	Cool pack
Available
Specificity	Human,Mouse
Manufacturer - Type	Primary Antibodies
Shipping Temperature	Blue Ice
Storage Conditions	Store at -20˚ C. Avoid freeze / thaw cycles.
Molecular Weight	Observed: 130kDa
Manufacturer - Research Area	Cell Cycle, Neuroscience
Background	The protein encoded by this gene is an endogenous calpain (calcium-dependent cysteine protease) inhibitor. It consists of an N-terminal domain L and four repetitive calpain-inhibition domains (domains 1-4), and it is involved in the proteolysis of amyloid precursor protein. The calpain/calpastatin system is involved in numerous membrane fusion events, such as neural vesicle exocytosis and platelet and red-cell aggregation. The encoded protein is also thought to affect the expression levels of genes encoding structural or regulatory proteins. Alternatively spliced transcript variants encoding different isoforms have been described.
By Type	Cell Cycle, Neuroscience
Badges	KO
Modifications	None
Purification	Affinity purification
Validation	Antibody is Knockout validated.
Positive Control 1	A-549
Positive Control 2	SW480
Positive Control 3	MCF-7
Positive Control 4	HepG2
Positive Control 5	Mouse lung
Positive Control 6	Rat liver
Concentration	batch dependent
Buffer	PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Application Note	WB: 1:500 - 1:2000
Immunogen	A synthetic peptide corresponding to a sequence within amino acids 550-650 of human CAST (NP_001177371.1).
Clonality	Polyclonal
NCBI Official Name	calpastatin
NCBI Organism	Homo sapiens
User Note	Optimal dilutions for each application to be determined by the researcher.
Validation	Antibody is Knockout validated.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100 uL

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Delivery expected until 11/6/2025

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