POLR2A Rabbit pAb

Polyclonal Antibodies

Store at -20°C. Avoid freeze / thaw cycles.|Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

This gene encodes the largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The product of this gene contains a carboxy terminal domain composed of heptapeptide repeats that are essential for polymerase activity. These repeats contain serine and threonine residues that are phosphorylated in actively transcribing RNA polymerase. In addition, this subunit, in combination with several other polymerase subunits, forms the DNA binding domain of the polymerase, a groove in which the DNA template is transcribed into RNA.

A synthetic peptide corresponding to a sequence within amino acids 1-260 of human POLR2A (NP_000928.1).

217kDa

Epigenetics Nuclear Signaling, DNA Damage Repair, Protein phosphorylation, Neuroscience, Neurodegenerative Diseases.

5430

POLR2A