PUMA Rabbit mAb

Monoclonal Antibodies

Store at -20°C. Avoid freeze / thaw cycles.|Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.

This gene encodes a member of the BCL-2 family of proteins. This family member belongs to the BH3-only pro-apoptotic subclass. The protein cooperates with direct activator proteins to induce mitochondrial outer membrane permeabilization and apoptosis. It can bind to anti-apoptotic Bcl-2 family members to induce mitochondrial dysfunction and caspase activation. Because of its pro-apoptotic role, this gene is a potential drug target for cancer therapy and for tissue injury. Alternative splicing results in multiple transcript variants.

A synthetic peptide corresponding to a sequence within amino acids 100-193 of human PUMA (NP_055232.1)

18kDa

Cell Biology Developmental Biology, Apoptosis, Mitochondrial Control of Apoptosis, Endocrine Metabolism, Neuroscience, Neurodegenerative Diseases.

27113

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