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SLC6A4 Antibody (monoclonal) (M06)

SLC6A4 Antibody (monoclonal) (M06)

Item no.	ABC-AT3931a
Manufacturer	Abcepta
Amount	100 ug
Category	Neuroscience Molecular Targets for Neuroscience Antibodies ELISA Primary Antibodies Immunostaining
Type	Antibody Monoclonal
Format	Liquid
Applications	ELISA
Clone	2A9
Specific against	Human (Homo sapiens)
Host	Mouse
Isotype	IgG2a Kappa
Citations	Panic disorder and serotonergic genes (SLC6A4, HTR1A and HTR2A): Association and interaction with childhood trauma and parenting. Blaya C, et al. Neurosci Lett, 2010 Sep 10. PMID 20817074.Serotonin transporter polymorphism as a predictor for escitalopram treatment of major depressive disorder comorbid with alcohol dependence. Muhonen LH, et al. Psychiatry Res, 2010 Aug 26. PMID 20800901.Evidence for plasticity genotypes in a gene-gene-environment interaction: the TRAILS study. Nederhof E, et al. Genes Brain Behav, 2010 Aug 4. PMID 20738408.[Interaction effect of serotonin transporter gene and brain-derived neurotrophic factor on the platelet serotonin content in stroke patients]. Zh Nevrol Psikhiatr Im S S Korsakova, 2010. PMID 20738025.Association between serotonin transporter polymorphisms and problem behavior in adult males with intellectual disabilities. May ME, et al. Brain Res, 2010 Aug 21. PMID 20735998.
NCBI	NP_001036.1
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	Sodium-dependent serotonin transporter,5HT transporter,5HTT,Solute carrier family 6 member 4,SLC6A4,HTT,SERT
Similar products	SLC6A4, HTT, SERT, 5HTT, 5HT transporter, Sodium-dependent serotonin transporter, Solute carrier family 6 member 4
Available
Manufacturer - Targets	SLC6A4 (NP_001036, 181 a.a. ~ 252 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Bio Background	This gene encodes an integral membrane protein that transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons. The encoded protein terminates the action of serotonin and recycles it in a sodium-dependent manner. This protein is a target of psychomotor stimulants, such as amphetamines and cocaine, and is a member of the sodium:neurotransmitter symporter family. A repeat length polymorphism in the promoter of this gene has been shown to affect the rate of serotonin uptake and may play a role in sudden infant death syndrome, aggressive behavior in Alzheimer disease patients, and depression-susceptibility in people experiencing emotional trauma.
Clonality	Monoclonal
Gene Name	SLC6A4
Subtitle	Mouse monoclonal antibody raised against a partial recombinant SLC6A4.
Reactivity	H
Antigen Source	Human: ~~ Positive
Formulation	Clear, colorless solution in phosphate buffered saline, pH 7.2 .
Org Accession	NP_001036
Gene Description	solute carrier family 6 (neurotransmitter transporter, serotonin), member 4
Gene Summary	This gene encodes an integral membrane protein that transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons. The encoded protein terminates the action of serotonin and recycles it in a sodium-dependent manner. This protein is a target of psychomotor stimulants, such as amphetamines and cocaine, and is a member of the sodium:neurotransmitter symporter family. A repeat length polymorphism in the promoter of this gene has been shown to affect the rate of serotonin uptake and may play a role in sudden infant death syndrome, aggressive behavior in Alzheimer disease patients, and depression-susceptibility in people experiencing emotional trauma. [provided by RefSeq
Antigen Type	Recombinant Protein

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100 ug

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Delivery expected until 1/1/2026

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