Anti-beta3-Adrenoceptor (ext.)

Antibodies

Beta-3 adrenoceptor, Beta-3 adrenoreceptor, ADRB3, B3AR

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

Lyophilized powder. Reconstituted antibody contains phosphate buffered saline (PBS), pH 7.4

Beta-3 adrenoceptor, Beta-3 adrenoreceptor, ADRB3, B3AR - A Rabbit Polyclonal Antibody to β3-Adrenergic Receptor

Rat - 12/13 amino acid residues identical; human - 11/13 amino acid residues identical

Confirmed by amino acid analysis and mass spectrometry

0.8 mg/ml

2nd extracellular loop

Mouse

41116161

Adrenergic receptors (also called adrenoceptors) are the receptors for the catecholamines adrenaline and noradrenaline (called epinephrine and norepinephrine in the United States). Adrenaline and noradrenaline play important roles in the control of blood pressure, myocardial contractile rate and force, airway reactivity, and a variety of metabolic and central nervous system functions.Adrenergic receptors are members of the G-protein coupled receptor (GPCR) superfamily of membrane proteins. They share a common structure of seven putative transmembrane domains, an extracellular amino terminus, and a cytoplasmic carboxyl terminus.Adrenoceptors are divided into three types: α1, α2 and β-adrenoceptors. Each type is further divided into at least three subtypes: α1A, α1B, α1D, α2A, α2B, α2C, β1, β2, β3. 1, 2 Adrenoceptors are expressed in nearly all peripheral tissues and in the central nervous system.1, 2 The β3-adrenoceptor is insensitive to the commonly used β-antagonists and has often been referred to as the 'atypical' β-adrenoceptor. Mouse β3-adrenoceptor has two known splice variants; isoforms β3a-adrenoceptor and β3b-adrenoceptor. Both isoforms are expressed in white and brown adipose tissues.3 The β3b-adrenoceptor is highly expressed in brain.The β3- adrenoceptor has been found to play a key role in the lipolytic action of catecholamines.4