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Anti-CaV1.2

Anti-CaV1.2

Item no.	ALO-ACC-003-25ul
Manufacturer	Alomone
Amount	25 ul
Quantity options	0.2 ml 25 ul 50 ul
Category	Neuroscience Molecular Targets for Neuroscience Antibodies Immunohistochemistry Western Blot Immunofluorescence Primary Antibodies Immunochemistry
Type	Antibody Polyclonal
Format	Lyophilized
Applications	WB, IF, IHC, IC
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host	Rabbit
Isotype	IgG
Conjugate/Tag	Unconjugated
Purity	Affinity purified on immobilized antigen.
Formula	PBS pH7.4, 1% BSA with 0.05% sodium azide
Sequence	(C)TTKINMDDLQPSENEDKS, corresponding to amino acid residues 848-865 of rat CaV1.2
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Shipping Condition	Room temperature
Available
Specificity	Polyclonal
Manufacturer - Type	Antibodies
Manufacturer - Category	Antibodies
Manufacturer - Targets	Voltage-dependent L-type calcium channel subunit α1C
Country of Origin	Israel
Shipping Temperature	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Storage Conditions	Storage before Reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C - Storage after Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
Manufacturer - Format	Lyophilized powder. Reconstituted antibody contains phosphate buffered saline (PBS), pH 7.4
Short description	A Rabbit Polyclonal Antibody to CaV1.2 (CACNA1C) Channel
Description	Voltage-dependent L-type calcium channel subunit α1C - A Rabbit Polyclonal Antibody to CaV1.2 (CACNA1C) Channel
Clonality	Polyclonal
Homology	Mouse - identical; guinea pig - 17/18 amino acid residues identical; human, rabbit - 16/18 amino acid residues identical
Standard quality control of each lot	Western blot analysis
Peptide confirmation	Confirmed by amino acid analysis and mass spectrometry
Reconstitution	25 µl, 50 µl or 0.2 ml double distilled water (DDW), depending on the sample size.
Antibody Concentration After Reconstitution	0.8 mg/ml
Preservative	1% BSA, 0.05% NaN3
Part of Immunogen	Product Page antibodies - Part of Immunogen
Immunogen Location	Intracellular loop between domains II and III
Specificity	CACNA1C
Immunogen source species	Rat
PH	7, 4
UNSPSC	41116161
Ko Validate	yes
Antigen Preadsorption Control	1 µg peptide per 1 µg antibody
Scientific Background	All L-type calcium channels are encoded by one of the CaV1 channel genes. These channels play a major role as a Ca2+ entry pathway in skeletal, cardiac and smooth muscles as well as in neurons, endocrine cells and possibly in non-excitable cells such as hematopoetic and epithelial cells. All CaV1 channels are influenced by dihydropyridines (DHP) and are also referred to as DHP receptors.While the CaV1.1 and CaV1.4 isoforms are expressed in restricted tissues (skeletal muscle and retina, respectively), the expression of CaV1.2 is ubiquitous and CaV1.3 channels are found in the heart, brain and pancreas. Several peptidyl toxins are described that are specific L-type channel blockers, but so far no selective blocker for one of the CaV1 isoforms have been described. These include the Mamba toxins Calcicludine (#SPC-650), Calciseptine (#C-500) and FS-2 (#F-700).

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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ALO-ACC-003-25ul-safety-datasheet.pdf