Anti-CaValpha2delta-1 (extracellular)

Antibodies

Israel

Storage before Reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C - Storage after Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

A Rabbit Polyclonal Antibody to CACNA2D1 (CaVα2δ1 Subunit)

Polyclonal

Western blot analysis

25 µl, 50 µl or 0.2 ml double distilled water (DDW), depending on the sample size.

1% BSA, 0.05% NaN3

CACNA2D1

7, 4

yes

The α2δ1 protein, encoded by CACNA2D1, is an auxiliary subunit of the CaV (voltage-dependent calcium) channel multimer complex. Four α2δ isoforms were identified in mammalian genomes. They share some sequence, as well as structure, homology.1The protein product of the gene encoding α2δ is complex; it includes two separated proteins - the extracellular α2 peptide linked by disulfide bridges to the membrane spanning (single transmembrane helix) δ subunit.The α2δ1 subunit is highly expressed in skeletal muscle and brain. Its expression along with a pore forming CaV α1 subunit, result in larger CaV currents, probably due to improved trafficking of the α1 subunit to the plasma membrane.1-2 α2δ1 subunit was shown to be the target of the antiepileptic and analgesic drug Gabapentin.3