Guinea pig Anti-mGluR5 (extracellular) Antibody

Antibodies

Metabotropic glutamate receptor 5, GRM5, mGlu5, GPRC1E

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

Lyophilized powder

Metabotropic glutamate receptor 5, GRM5, mGlu5, GPRC1E - A Guinea Pig Polyclonal Antibody to Metabotropic Glutamate Receptor 5

Mouse - identical; human - 13/14 amino residues identical

Confirmed by amino acid analysis and mass spectrometry

0.8 mg/ml

Extracellular, N-terminus

Rat

41116161

Metabotropic glutamate G protein-coupled receptors are divided into three groups on the basis of their sequence similarity, pharmacology and signal transduction mechanisms. mGluR5 is a class I mGlu receptor and is widely expressed throughout the cortex, hippocampus, striatum, caudate nucleus and nucleus accumbens, areas involved in emotion, motivation and cognition. mGluR5 is primarily located post-synaptically and is coupled to the Gq/11 pathway.mGluR5 is comprised of an extracellular N-terminus, an intracellular C-terminus and seven transmembrane α helices (TM1-7). Native ligands can bind to the receptor's extracellular domain. This extracellular binding is consistent with the narrow allosteric pocket the receptor possesses due to the tight configuration of its helical bundle1. mGluR5 is physically coupled to NMDA receptors by various scaffolding proteins including PSD-95, Shank, and Homer, as well as via a direct interaction. In addition, mGluR5 is biochemically coupled to NMDA receptor function via PKC. As a result of these molecular and biochemical interactions, activation of mGluR5 results in enhanced functionality of the NMDA receptor.mGluR5 is also involved in dendrogenesis and spineogenesis. mGluR5−/− knockout mice exhibit elevated spine densities irrespective of spine type or location along their dendritic trees in comparison to mGluR5+/− animals2.Recent studies have shown that mGluR5 is a critical mediator and a potential therapeutic target for the treatment of numerous disorders of the central nervous system, including depression, anxiety, drug addiction, chronic pain, Fragile X syndrome, Parkinson's disease, and gastroesophageal reflux disease3.