Anti-Vesicular GABA Transporter

Antibodies

Vesicular inhibitory amino acid transporter, VIAAT, GABA and glycine transporter, SLC32A1

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

Lyophilized powder. Reconstituted antibody contains phosphate buffered saline (PBS), pH 7.4

Vesicular inhibitory amino acid transporter, VIAAT, GABA and glycine transporter, SLC32A1 - A Rabbit Polyclonal Antibody to Vesicular GABA Transporter

Mouse, human - identical

Confirmed by amino acid analysis and mass spectrometry

1 mg/ml

Cytoplasmic, N-terminus

Rat

41116161

The superfamily of amino acid transporters includes SLC32, SLC36 and SLC38 families. SLC32 has only one member, the vesicular inhibitory amino acid transporter (VIAAT) or vesicular GABA transporter (VGAT)1.VGAT is responsible for the uptake of GABA and glycine in exchange of protons, and their release from nerve terminals1.The transporter is organized into ten membrane spanning domains, a cytosolic N-terminus and a luminal C-terminal tail2. In many regions in the brain, where it is expressed, it is found constitutively phosphorylated, although the biological significance is currently unknown3.VGAT is expressed on synaptic vesicles of GABAergic and glycinergic neurons4-6. The transporter is also detected in the pituitary gland and in the pancreas7, 8.