Anti-SLC6A15

Antibodies

Solute carrier family 6 member 15, Sodium-dependent neutral amino acid transporter B(0)AT2, Sodium-and chloride-dependent neurotransmitter transporter NTT73, NTT73, B0AT2, SBAT1

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

Lyophilized powder. Reconstituted antibody contains phosphate buffered saline (PBS), pH 7.4

Solute carrier family 6 member 15, Sodium-dependent neutral amino acid transporter B(0)AT2, Sodium-and chloride-dependent neurotransmitter transporter NTT73, NTT73, B0AT2, SBAT1 - A Rabbit Polyclonal Antibody to SLC6A15 Transporter

Rat, human - identical

Confirmed by amino acid analysis and mass spectrometry

0.8 mg/ml

Intracellular, C-terminus.

Mouse

41116161

Sodium-dependent neutral amino acid transporter B(0)AT2, encoded by SLC6A15 gene, is a member of SLC6 neuro transporters family 1.This transporter mediates sodium-dependent, electrogenic transport of leucine and other branched chain amino acids (BCAA). It was found to be expressed in a small percentage of neurons in the hippocampus, the amygdala and other limbic regions as well as in the olfactory bulb, the cortex and the cerebellum 2. Its structure is composed of twelve transmembrane domains, and the ligand-binding site is conserved between mammals and bacteria 3. Since it is active in regulation of the cellular levels of leucine and other BCAA, its activity is related to food intake, body weight and other obesity-related phenotypes 1.In addition to that, BCAA levels and regulated uptake is important for the proper morphology and functions of different brain areas and indeed, one single nucleotide polymorphism (SNP) in SLC6A15 was found to significantly increase the risk of suffering from depression and this polymorphism was also found to affect hippocampal morphology, integrity, and hippocampus-dependent memory 4.These findings emphasize SLC6A15 as pivotal risk factor for vulnerability to psychiatric diseases and makes it an appealing target for drug design.