Anti-slobeta4 (KCNMB4)

Antibodies

Ca2+-activated K+ channel subunit β4, BKCa β subunit 4, BK beta4, Maxi K channel β4, Charybdotoxin receptor subunit beta-4

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

Lyophilized powder. Reconstituted antibody contains phosphate buffered saline (PBS), pH 7.4

Ca2+-activated K+ channel subunit β4, BKCa β subunit 4, BK beta4, Maxi K channel β4, Charybdotoxin receptor subunit beta-4 - A Rabbit Polyclonal Antibody to slo?4 (KCNMB4) Subunit

Mouse, human - identical

Confirmed by amino acid analysis and mass spectrometry

0.8 mg/ml

Intracellular, N-terminal domain

Rat

41116161

sloβ4 is a member of a family of regulatory β subunits that control the activity of the large conductance Ca2+-activated K+ channel, KCa1.1. The family includes four members with a shared topology: two transmembrane domains, short intracellular N- and C-termini and a large extracellular region.The four members of the family have a distinct tissue distribution with sloβ4 expressed almost exclusively in the central nervous system (CNS).Functionally, sloβ4 increases the sensitivity of the pore-forming KCa1.1 subunit to Ca2+ and voltage and it also changes its pharmacology. It has been shown that co-expression of sloβ4 with KCa1.1 makes the latter resistant to nanomolar concentrations of the well-known inhibitors charybdotoxin and iberiotoxin.The physiological significance of sloβ4 expression in the CNS is not clear, but KCa1.1 channels are likely involved in the regulation of neurotransmitter release in presynaptic terminals.