Anti-Kir6.1

Antibodies

ATP-sensitive inward rectifier potassium channel 8, uKATP-1

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

Lyophilized powder. Reconstituted antibody contains phosphate buffered saline (PBS), pH 7.4

ATP-sensitive inward rectifier potassium channel 8, uKATP-1 - A Rabbit Polyclonal Antibody to Kir6.1 (KCNJ8) Channel

Mouse, human, pig, rabbit - 15/16 amino acid residues identical

Confirmed by amino acid analysis and mass spectrometry

0.8 mg/ml

Intracellular, C-terminal domain

The antibody is specific for Kir6.1 and does not cross react with Kir6.2.

7, 4

yes

Kir6.1 is a member of the inward rectifier K+ channels (Kir channels), a large family of voltage-independent K+ channels largely involved in stabilization of the membrane resting potential and in K+ transport across membranes.Kir6.1, like its close relative Kir6.2, is highly sensitive to inhibition by intracellular ATP. Closure of the channel leads to membrane depolarization thereby coupling intracellular metabolism to cellular excitability.Kir6.1 presents the common topology of the inward-rectifier superfamily: two transmembrane domains flanking a highly conserved pore region with the N- and C-termini located intracellularly.The functional ATP sensitive channel (KATP) is composed of octamers of four Kir6.x subunits and four members of the sulfonylurea receptor family SUR1, SUR2A and SUR2B.The channel's tissue distribution is relatively broad with expression detected in heart, brain, and smooth muscle.