Anti-DPP6 (extracellular)

Antibodies

Dipeptidyl peptidase 6, Dipeptidyl aminopeptidase-like protein 6, DPP VI, DPPX, VF2

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

Lyophilized powder. Reconstituted antibody contains phosphate buffered saline (PBS), pH 7.4

Dipeptidyl peptidase 6, Dipeptidyl aminopeptidase-like protein 6, DPP VI, DPPX, VF2 - A Rabbit Polyclonal Antibody to Dipeptidyl Peptidase 6

Rat, mouse - identical

Confirmed by amino acid analysis and mass spectrometry

0.8 mg/ml

Extracellular, C-terminus

Human

41116161

Dipeptidyl-peptidase 6 (DPP6) is a type II membrane glycoprotein1 which is a part of the dipeptydil aminopeptidase-like proteins (DPPLs) subfamily. It is an auxiliary glycoproteinic subunit of voltage-dependent K+ channel 4 (KV4.x), that has a short cytoplasmic domain, a long extracellular domain and a transmembrane domain. It regulates sub-threshold, A-type K+ currents, and is important for the enhancement and localization of KV4.2 channels2.DPPLs are a subgroup of the larger prolyl oligopeptidase family. A loss-of-function mutation at their enzymatic serine renders them incapable of cleaving peptides. Notable DPPLs include DPP8, DPP9, and DPPIV - the latter is known to regulate several key functions in varied systems, ranging from immune to CNS1, 3.Alternative mRNA splicing of the DPP6 gene (part of the di-genic DPLP group that also consists DPP10) gives rise to several isoforms that differ in their N-terminal (DPP6a, DPP6K, DPP6S, DPP6L DPP6E)4.DPP6 proteins are widely expressed throughout both of the nervous systems - albeit much more predominantly in the CNS - and are known to play a major role in neurogenesis and neurodevelopment5.Deletion mutations and haplo-insufficiency of the DPP6 gene has been shown to be associated with autism spectrum disorder, Gilles de la Tourette syndrome, dominant microcephaly and mental retardation5, 6. Endometriosis - a condition characterized by extra-uteral endometrial glands that affects one tenth of fertile women population - has been linked with DPP6 in genome wide associations studies (GWASs)7.