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Anti-SAP-97

Anti-SAP-97

Item no.	ALO-APZ-010-25ul
Manufacturer	Alomone
Amount	25 ul
Quantity options	0.2 ml 25 ul 50 ul
Category	Neuroscience Neural Signaling Antibodies Western Blot Primary Antibodies
Type	Antibody Polyclonal
Format	Lyophilized
Applications	WB
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host	Rabbit
Isotype	IgG
Conjugate/Tag	Unconjugated
Purity	Affinity purified on immobilized antigen.
Formula	PBS pH7.4, 1% BSA with 0.05% sodium azide
Sequence	(C)EYRSKLSQTEDRQLR, corresponding to amino acid residues 17-31 of human SAP-97
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Shipping Condition	Room temperature
Available
Specificity	Polyclonal
Manufacturer - Type	Antibodies
Manufacturer - Category	Antibodies
Manufacturer - Targets	Synapse-associated protein 97, Discs large homolog 1
Country of Origin	Israel
Shipping Temperature	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Storage Conditions	Storage before Reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C - Storage after Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
Manufacturer - Format	Lyophilized powder. Reconstituted antibody contains phosphate buffered saline (PBS), pH 7.4
Short description	A Rabbit Polyclonal Antibody to SAP-97
Description	Synapse-associated protein 97, Discs large homolog 1 - A Rabbit Polyclonal Antibody to SAP-97
Clonality	Polyclonal
Homology	Rat, mouse - identical
Standard quality control of each lot	Western blot analysis
Peptide confirmation	Confirmed by amino acid analysis and mass spectrometry
Reconstitution	25 μl, 50 μl or 0.2 ml double distilled water (DDW), depending on the sample size.
Antibody Concentration After Reconstitution	0.8 mg/ml
Preservative	1% BSA, 0.05% NaN3
Immunogen Location	N-terminus, L27 domain
Specificity	DLG1
Immunogen source species	Human
PH	7, 4
UNSPSC	41116161
Antigen Preadsorption Control	1 µg peptide per 1 µg antibody
Scientific Background	SAP-97 belongs to the MAGUK (membrane associated guanylate kinase) homologs along with PSD-95, PSD-93 and SAP102.Like other members, SAP-97 has three PDZ domains, one SH3 domain and an inactive GUK domain. Alternative splicing of SAP-97 gives to a number of different isoforms thereby complicating the understanding of its roles1.In the post-synaptic cell, SAP-97 is the only MAGUK to directly interact with the GluA1 AMPA receptor2. SAP-97 also directly interacts with NMDA receptors through the PDZ domain3, 4.SAP-97 was shown to interact with KV1.45 and with KV4.2 where it directs the channel to spines in hippocampal neurons6. It can also interact with the channel in the heart7.Interactions with Kir channels have also been observed8, 9.Thus, SAP-97 serves as a regulator of neuronal excitability and synaptic function. Roles for the protein in schizophrenia, Alzheimer's and Parkinson's disease and epilepsy have been found1.

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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ALO-APZ-010-25ul-safety-datasheet.pdf